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TLS Online TPP Program

#Id: 5629

The sensory receptors for vision are photoreceptors, located on the retina.

#Unit 7. System Physiology – Animal #Sense Organs #Part B Pointers
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TLS Online TPP Program

#Id: 7930

#Unit 2. Cellular Organization

Secretory pathway
pathway of protein trafficking that flows through the ER
TLS Online TPP Program

#Id: 7931

#Unit 2. Cellular Organization

Microsomes
when cells are homogenized, the rough ER breaks up into small closed vesicles with ribosomes on the outside
TLS Online TPP Program

#Id: 7932

#Unit 2. Cellular Organization

Signal sequence

ER targeting sequence, located at the N-terminus of the protein
TLS Online TPP Program

#Id: 7933

#Unit 2. Cellular Organization

Signal sequences

contain one or more positively charged amino acids adjacent to a continuous stretch of 6–12 hydrophobic residues (known as the hydrophobic core)
TLS Online TPP Program

#Id: 7934

#Unit 2. Cellular Organization

The two key components in protein targeting in ER:
Signal recognition particle (SRP)
SRP receptor
TLS Online TPP Program

#Id: 7935

#Unit 2. Cellular Organization

The SRP is a cytosolic ribonucleoprotein particle that transiently binds to both the ER signal sequence in a nascent protein and the large (60S) ribosomal subunit, forming a large complex.