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Class II MHC transcriptional activator called CIITA and another transcription factor called RFX, have both been shown to activate the promoter of class II MHC genes.
Defects in these transcription factors cause one form of bare lymphocyte syndrome.

#Unit 4. Cell Communication and Cell Signaling #MHC molecules #Part B Pointers
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TLS Online TPP Program

#Id: 951

#Unit 5. Developmental Biology

In sea urchin, the acrosome reaction has 2 components:
1. Exocytosis
2. Extension of the acrosomal process

TLS Online TPP Program

#Id: 952

#Unit 5. Developmental Biology

In sea urchins, the acrosome reaction is initiated by sulfate-containing polysaccharides in the egg jelly.

TLS Online TPP Program

#Id: 953

#Unit 5. Developmental Biology

In Strongylocentrotus purpuratus, the acrosome reaction is initiated by a repeating polymer of fucose sulfate.

TLS Online TPP Program

#Id: 954

#Unit 5. Developmental Biology

When sulfated polysaccharide binds to its receptor on the sperm, activates 3 sperm membrane proteins: 
(1) A calcium transport channel
(2) A sodium-hydrogen exchanger
(3) A phospholipase enzyme (IP3)

TLS Online TPP Program

#Id: 955

#Unit 5. Developmental Biology

Extension of the acrosomal process by the polymerization of G-actin molecules into F-actin by RhoB

TLS Online TPP Program

#Id: 956

#Unit 5. Developmental Biology

Acrosomal process have an insoluble, 30,500-Da protein called bindin.

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