Outer membrane of gram negative provides barrier to certain antibiotics, lysozyme, detergents, heavy metals, bile salts, etc.

TLS Online TPP Program

#Id: 412

#Unit 2. Cellular Organization

The H2A variants are the largest and most diverse family of core histone variants.

TLS Online TPP Program

#Id: 413

#Unit 2. Cellular Organization

H2AX is normally present in only 10%–15% of the nucleosomes in multicellular eukaryotes

TLS Online TPP Program

#Id: 414

#Unit 2. Cellular Organization

H2AX subtype is has a C-terminal tail that is distinct from the canonical H2A, characterized by a SQEL/Y motif at the end.

TLS Online TPP Program

#Id: 415

#Unit 2. Cellular Organization

SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair

TLS Online TPP Program

#Id: 416

#Unit 2. Cellular Organization

H2AX phosphorylated at the SQEL/Y motif is sometimes referred to as “gamma-H2AX,”

TLS Online TPP Program

#Id: 417

#Unit 2. Cellular Organization

Gamma-H2AX frequently functions in DSBR