Sensory receptors show adaptation, when a constant stimulus is applied for a period of time. Pattern of adaptation are phasic (adapt rapidly to the stimulus)& tonic(adapt slowly to the stimulus)

TLS Online TPP Program

#Id: 1419

#Unit 4. Cell Communication and Cell Signaling

An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β.

TLS Online TPP Program

#Id: 1420

#Unit 4. Cell Communication and Cell Signaling

Integrins function as transmembrane linkers (integrators) between the extracellular matrix and the actin cytoskeleton.

TLS Online TPP Program

#Id: 1421

#Unit 4. Cell Communication and Cell Signaling

Integrins bind extracellular matrix (ECM) glycoproteins, 1. Laminins  

2. Collagens 

3. Fibronectin

4. Vitronectin

TLS Online TPP Program

#Id: 1422

#Unit 4. Cell Communication and Cell Signaling

Fibronectin binds to integrin through an RGD motif.

TLS Online TPP Program

#Id: 1423

#Unit 4. Cell Communication and Cell Signaling

The binding of integrins to their ligands depends on extracellular divalent cations(Ca+2 & Mg+2).

TLS Online TPP Program

#Id: 1424

#Unit 4. Cell Communication and Cell Signaling

The α subunit of each integrin is the primary determinant of its extracellular ligand specificity.