One major problem is that this approach does not take species frequency of occurrence or relative abundance into account.

TLS Online TPP Program

#Id: 10060

#Unit 4. Cell Communication and Cell Signaling

The formation of many cell-cell adhesions entails two types of molecular interactions:

1.Trans binding interactions 

2. Cis binding interactions

TLS Online TPP Program

#Id: 10061

#Unit 4. Cell Communication and Cell Signaling

Trans interactions (intercellular or adhesive interactions)

CAMs on one cell bind to CAMs on an adjacent cell. 

TLS Online TPP Program

#Id: 10062

#Unit 4. Cell Communication and Cell Signaling

In cis interactions (intracellular or lateral interactions)

monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane

TLS Online TPP Program

#Id: 10063

#Unit 4. Cell Communication and Cell Signaling

CAMs fall into one of four major families: 

Cadherins

Immunoglobulin (Ig) superfamily

Integrins

Selectins

TLS Online TPP Program

#Id: 10064

#Unit 4. Cell Communication and Cell Signaling

The adhesiveness of cadherins depends on the presence of extracellular Ca2+

TLS Online TPP Program

#Id: 10065

#Unit 4. Cell Communication and Cell Signaling

Two type of Cadherins:

1. Classical cadherin proteins

2. Nonclassical cadherin proteins