Colloid consists predominantly of the glycoprotein, thyroglobulin

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#Unit 4. Cell Communication and Cell Signaling

During apoptosis

caspase-3 cleaves the inactive phospholipid scramblase XKR8. 

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

After cleavage by caspase-3, truncated XKR8, together with either basigin (BSG) or neuroplastin (NPTN), undergoes dimerization and activation and translocates

phospholipids in both directions.

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#Unit 4. Cell Communication and Cell Signaling

By scramblase, appearance of phosphatidylserine on the outer surface, act as “eat me” signal

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#Unit 4. Cell Communication and Cell Signaling

eat me” signal, recognize by a set of receptors on the surface of macrophages and other immune system cells, triggering phagocytosis of the cell or apoptotic body.

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#Unit 4. Cell Communication and Cell Signaling

Annexin V

a 36-kDa calcium-binding protein, binds to PS; used to detect PS that is exposed on the outside of apoptotic cells

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

All members of the Bcl-2 family share a close homology in up to four characteristic regions, termed the Bcl-2 homology domains