TLS Online TPP Program

#Id: 1499

#Unit 4. Cell Communication and Cell Signaling

P53 turned on sets of large intergenic noncoding RNAs to mediate transcription repression; and miRNAs.

TLS Online TPP Program

#Id: 1500

#Unit 4. Cell Communication and Cell Signaling

p2I -IincRNA, mediates the repressive properties of p53 by binding to specific chromatin complexes.

TLS Online TPP Program

#Id: 1501

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.

 

TLS Online TPP Program

#Id: 1502

#Unit 4. Cell Communication and Cell Signaling

p53 amyloid aggregates,

No transport from cytoplasm to the nucleus

Escape proteasome degradation

TLS Online TPP Program

#Id: 1503

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 demonstrated by biophysical techniques:

X-ray diffraction 

Fourier transform infrared spectroscopy (FTIR)

TLS Online TPP Program

#Id: 3196

#Unit 4. Cell Communication and Cell Signaling

Mutations in three broad classes of genes play key roles in cancer induction: 

Proto-oncogenes genes
Tumor-suppressor genes
Genome maintenance genes