As cells enter into the S phase of the cell cycle, two kinases, CDK and DDK, are activated. DDK phosphorylates loaded Mcm2-7 helicase, and CDK phosphorylates Sld2 and Sld3.Phosphorylated Sld2 and Sld3 bind to Dpb11, and together these proteins facilitate binding of the helicase-activating proteins, Cdc45 and GINS, to the helicase.
#Unit 3. Fundamental Processes#Eukaryotic DNA Replication#Part B Pointers
