RFC is a clamp loader that catalyzes the loading of PCNA onto DNA. It binds to the 3’ end of the DNA and uses ATP hydrolysis to open the ring of PCNA so that it can encircle the DNA.

TLS Online TPP Program

#Id: 8885

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8886

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8887

#Unit 2. Cellular Organization

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

TLS Online TPP Program

#Id: 8888

#Unit 2. Cellular Organization

A key function of mitotic CDKs, together with other protein kinases and ubiquitin-protein ligases, is to induce the formation of the mitotic spindle, also known as the mitotic apparatus.

TLS Online TPP Program

#Id: 8889

#Unit 2. Cellular Organization

Centrosomes contain γ tubulin, which forms specific ringlike complexes (γ TuRCs) that, have the ability to nucleate microtubules and form a bipolar spindle

TLS Online TPP Program

#Id: 8890

#Unit 2. Cellular Organization

Mitotic spindle attach to chromosomes via specialized protein structures known as kinetochores