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TLS Online TPP Program

#Id: 6122

The deamination generates a G-T/C-T mismatch pair, MutL and MutS remove T from both G-T and C-T mismatches.

#Unit 3. Fundamental Processes #Mutation and Repair #Part B Pointers
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TLS Online TPP Program

#Id: 8563

#Unit 1. Molecules and their Interaction Relevant to Biology

Substrate-binding could cause a conformational change to take place in the enzyme and reveal an inhibitor binding site, or the inhibitor could bind directly to the enzyme-bound substrate. 
TLS Online TPP Program

#Id: 8564

#Unit 1. Molecules and their Interaction Relevant to Biology
TLS Online TPP Program

#Id: 8565

#Unit 1. Molecules and their Interaction Relevant to Biology

In the simplest possible model, simple linear non-competitive inhibition, the substrate does not affect inhibitor-binding. 
TLS Online TPP Program

#Id: 8566

#Unit 1. Molecules and their Interaction Relevant to Biology

Under these conditions, the reactions have an identical dissociation constant Ki , again called the inhibitor constant. 
TLS Online TPP Program

#Id: 8568

#Unit 1. Molecules and their Interaction Relevant to Biology

In the presence of a non-competitive inhibitor which will bind equally well to E or to ES- Vmax decreases but not Km 
TLS Online TPP Program

#Id: 8569

#Unit 1. Molecules and their Interaction Relevant to Biology

In case of nonidentical dissociation constants, MIXED TYPE INHIBITION TAKES PLACE