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TLS Online TPP Program

#Id: 6131

1-methyladenine and 3MC is corrected by an enzyme that uses an oxygenating mechanism alkB by reversal mechanism


#Unit 3. Fundamental Processes #Mutation and Repair #Part B Pointers
PYQ Links
  1. PYQ 1
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TLS Online TPP Program

#Id: 9474

#Unit 4. Cell Communication and Cell Signaling

SHP1 
Binding of an SH2 domain to a phosphotyrosine in the activated receptor unmasks its phosphatase catalytic site
TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.
TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 
expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods
TLS Online TPP Program

#Id: 9477

#Unit 4. Cell Communication and Cell Signaling

All SOCS proteins contains:
SH2 domain
SOCS box
TLS Online TPP Program

#Id: 9478

#Unit 4. Cell Communication and Cell Signaling

SOCS box, 
Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome
TLS Online TPP Program

#Id: 9479

#Unit 4. Cell Communication and Cell Signaling

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity