The carboxy-terminal domain of the a subunit (aCTD) recognizes the Up-element (where present), whereas s regions 2 and 4 recognize the –10 and –35 regions

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Vimentin, found in mesenchymal cells;

GFAP (glial fibrillary acidic protein), found in glial cells

Desmin, found in muscle cells

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#Unit 2. Cellular Organization

In smooth muscle, desmin filaments link cytoplasmic dense bodies to the plasma membrane to ensure that cells resist overstretching.

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In skeletal muscle, 

The desmin filaments encircle the Z disk and are cross-linked to the plasma membrane. 

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Type IV Ifs consist of the three related subunits

NF-L, NF-M, and NF-H that make up the neurofilaments found in the axons of neurons

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Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) 

neurodegenerative disease 

associated with an accumulation and abnormal assembly

of neurofilaments in motor neuron cell bodies and in the axon

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In humans, three genes encode lamins: 

Lamins A and C (alternatively spliced gene) 

Lamins B1 and B2