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An additional DNA element that binds RNA polymerase is found in some strong promoters, for example, those directing expression of the ribosomal RNA (rRNA) genes. This is called an UP-element and increases polymerase binding by providing an additional specific interaction between the enzyme and the DNA.


#Unit 3. Fundamental Processes #Prokaryotic Transcription #Part B Pointers
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#Unit 2. Cellular Organization

Kinesin-1 
is regulated by a 
head-to-tail interaction

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#Unit 2. Cellular Organization

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#Unit 2. Cellular Organization

Other proteins function with dynein & involved in regulating the activity of dynein during brain development:
LIS1 and NudE


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#Unit 2. Cellular Organization

Defects in LIS1 
Miller-Dieker lissencephaly
means “smooth brain”

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#Unit 2. Cellular Organization


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#Unit 2. Cellular Organization

Post-translational modifications of tubulin:
Lysine acetylation
Detyrosylation
Polyglutamylation
Polyglycylation

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