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Leaky Expression
In repressed state, an occasional transcript gets made. This happens because every so often, RNA polymerase will manage to bind the promoter in place of the Lac repressor. This leakiness encode meager level of Z, Y and A.

#Unit 2. Cellular Organization #CELL CYCLE #Part B Pointers
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#Unit 8. Inheritance Biology

Segmental duplications have played an important role in the evolution of human chromosomes; about 4% of the human genome consists of segmental duplications. 


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#Unit 8. Inheritance Biology

Unbalanced gene dosage leads to developmental abnormalities.


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#Unit 8. Inheritance Biology

Chromosome deletion 

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#Unit 8. Inheritance Biology

Chromosome deletion - Loss of a chromosome segment.

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#Unit 8. Inheritance Biology

Deletion include,
Terminal deletion
ntercalary/interstitial deletion 
Microdeletion

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#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm
Wolf– Hirschhorn syndrome- Deletion on 4, short arm
Williams– Beuren syndrome - Deletion on 7, long arm
Prader– Willi syndrome- Deletion on 15 long arm 

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