These two mechanisms, (1) binding of the capping enzyme to RNA polymerase II specifically through its unique CTD phosphorylated on serine 5 of the heptapeptide repeat during transcription initiation by TFIIH, and (2) activation of the capping enzyme by the serine 5–phosphorylated CTD, result in specific capping of RNAs transcribed by RNA polymerase II.
#Unit 3. Fundamental Processes#Eukaryotic Transcription#Part B Pointers
