Glucocorticoids are apparently necessary for the normal development of the adrenal medulla

TLS Online TPP Program

#Id: 10515

#Unit 4. Cell Communication and Cell Signaling

XIAP has N-terminal BIR domains: 

BIR2 - binds to and inhibits caspase-3 and caspase-7

BIR3 - binds to and inhibits initiator caspase-9

TLS Online TPP Program

#Id: 10516

#Unit 4. Cell Communication and Cell Signaling

Bax or Bak oligomers leads to the release of SMAC/DIABLOs, from the mitochondrial IMS which binds to XIAP in the cytosol & blocking XIAP from binding to caspases. 

TLS Online TPP Program

#Id: 10517

#Unit 4. Cell Communication and Cell Signaling

Caspases

are so named because they contain a key cysteine residue in the catalytic site and selectively cleave proteins at sites just C-terminal to aspartate residues

TLS Online TPP Program

#Id: 10518

#Unit 4. Cell Communication and Cell Signaling

Caspases function as homodimers with one domain of each stabilizing the active site of the other; they mediate apoptosis by proteolytic cleavage of selected substrates

TLS Online TPP Program

#Id: 10519

#Unit 4. Cell Communication and Cell Signaling

During apoptosis, increasing amounts of phosphatidylserine are found in the exoplasmic leaflet, where it acts as an “eat me” signal

TLS Online TPP Program

#Id: 10520

#Unit 4. Cell Communication and Cell Signaling

In normal vertebrate cells, ATP-powered phospholipid flippases  (members of the ABC transporter) called 

ATP11A and ATP11C