Insulin, 

synthesized and secreted 

by the β cells

TLS Online TPP Program

#Id: 7789

#Unit 2. Cellular Organization

Nuclear transport receptor

A general class of proteins that facilitate protein transport into or out of the nucleus by binding to a nuclear import sequence or a nuclear export sequence

TLS Online TPP Program

#Id: 7790

#Unit 2. Cellular Organization

Nuclear transport receptor

have affinity for FG-repeats on nucleoporins.

TLS Online TPP Program

#Id: 7791

#Unit 2. Cellular Organization

The mechanism for the import of cytoplasmic cargo proteins mediated by a nuclear transport receptor known as importin.

TLS Online TPP Program

#Id: 7792

#Unit 2. Cellular Organization

Ran is a small monomeric G protein

That exists in either a GTP-bound or a GDP-bound conformation & provides the energy to drive unidirectional transport of macromolecules through the nuclear pore.

TLS Online TPP Program

#Id: 7793

#Unit 2. Cellular Organization

Nuclear-export signal (NES)

ribonuclear protein complexes that shuttle between the nucleus and the cytoplasm. Such shuttling proteins contain NES.

TLS Online TPP Program

#Id: 7794

#Unit 2. Cellular Organization

Shuttling protein have identified at least three different types of NESs: 

A. A leucine-rich sequence found in PKI 

B. In the Rev protein of human immunodeficiency virus (HIV)

C. In two heterogeneous ribonucleoprotein particles (hnRNPs)