MIS is a 536-amino-acid homodimer a member of the TGF-β superfamily

TLS Online TPP Program

#Id: 10043

#Unit 4. Cell Communication and Cell Signaling

Poly-K63 ubiquitin chain brings TAK1 kinase and β subunit of I-κB

kinase, into close proximity so that TAK1 can phosphorylate and activate I-κB kinase

TLS Online TPP Program

#Id: 10044

#Unit 4. Cell Communication and Cell Signaling

In Notch/Delta pathway, 

signaling molecule is Delta, an integral membrane protein bound to the surface of the signaling cell.

TLS Online TPP Program

#Id: 10045

#Unit 4. Cell Communication and Cell Signaling

In Notch/Delta pathway, 

Notch is receptor protein, on a neighboring responding cell

TLS Online TPP Program

#Id: 10046

#Unit 4. Cell Communication and Cell Signaling

In the absence of Delta, 

TM subunit of Notch on the surface of a responding cell is non-covalently associated with its extracellular subunit; extracellular domain is folded

TLS Online TPP Program

#Id: 10047

#Unit 4. Cell Communication and Cell Signaling

Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

TLS Online TPP Program

#Id: 10048

#Unit 4. Cell Communication and Cell Signaling

ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.