TLS Online TPP Program

#Id: 8349

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8350

#Unit 2. Cellular Organization

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.

TLS Online TPP Program

#Id: 8351

#Unit 2. Cellular Organization

WASp activation requires two signals (This type of two-signal input, called coincidence detection):

1. regulatory phospholipid PIP2

2. small GTP-binding protein Cdc42

TLS Online TPP Program

#Id: 8353

#Unit 2. Cellular Organization

A second NPF is a large protein complex called WAVE

and requires small GTP-binding protein Rac1.

TLS Online TPP Program

#Id: 8354

#Unit 2. Cellular Organization

Listeria is a food-borne bacterial pathogen has on its surface a protein ActA, which mimics an NPF that efficiently activates the Arp2/3 complex.

TLS Online TPP Program

#Id: 8356

#Unit 2. Cellular Organization

ActA protein binds the host protein VASP, which enhance actin assembly and confine it to the rear of the bacterium.