In nonsense mediated decay  in the addition of multiple lysines to the end of the protein (AAA is the codon for lysine) and stalling of the ribosome at the end of the mRNA. 

TLS Online TPP Program

#Id: 2314

#Unit 3. Fundamental Processes

There are three type of Splicing Machinery

 

TLS Online TPP Program

#Id: 2315

#Unit 3. Fundamental Processes

The group I and group II introns have the remarkable ability to excise themselves from an RNA. This is called auto-splicing, or self-splicing. 

Group I introns are more common than group II introns.

TLS Online TPP Program

#Id: 2316

#Unit 3. Fundamental Processes

Two transesterification reactions takes place for 2 exon -1 intron configuration. First transesterification is catalysed variably either by external G or branch point while second transesterification is always caused by exon 1 -3’OH.

 

TLS Online TPP Program

#Id: 2317

#Unit 3. Fundamental Processes

There are three type of Splicing signals 

Major U2-type or GU-AG introns

Minor U12-type or AU-AC introns

Minor U12-type with GU-AG introns (hybrid type)

TLS Online TPP Program

#Id: 2318

#Unit 3. Fundamental Processes

Major U2-type or GU-AG introns

TLS Online TPP Program

#Id: 2319

#Unit 3. Fundamental Processes

Splicing signals for minor introns