Shelterin proteins bound at the telomere distinguish telomeres from other DNA ends in the cell prevents telomeres from normal DSBR

TLS Online TPP Program

#Id: 6290

#Unit 3. Fundamental Processes

Consensus Sequences

TLS Online TPP Program

#Id: 6291

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6292

#Unit 3. Fundamental Processes

The carboxy-terminal domain of the a subunit (aCTD) recognizes the Up-element (where present), whereas s regions 2 and 4 recognize the –10 and –35 regions

TLS Online TPP Program

#Id: 6293

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6294

#Unit 3. Fundamental Processes

In holoenzyme Region 1.1 of s is highly negatively charged hence region 1.1 acts as a molecular mimic of DNA

TLS Online TPP Program

#Id: 6295

#Unit 3. Fundamental Processes

An additional DNA element that binds RNA polymerase is found in some strong promoters, for example, those directing expression of the ribosomal RNA (rRNA) genes. This is called an UP-element and increases polymerase binding by providing an additional specific interaction between the enzyme and the DNA.