Pointers

  1. Home
  2. Free Resources
  3. Pointers
  4. 6864
TLS Online TPP Program

#Id: 6864

Su(var) mutations lie in genes whose products are needed for the formation of heterochromatin such as HDAC, HMT.



#Unit 3. Fundamental Processes #Eukaryotic Chromosome Architecture #Part B Pointers
PYQ Links
  1. PYQ 1
Extensive Links
  1. Link 1
More Pointers
TLS Online TPP Program

#Id: 8933

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8934

#Unit 2. Cellular Organization

Spindle assembly checkpoint pathway is active until every single kinetochore has attached properly to spindle microtubules
TLS Online TPP Program

#Id: 8935

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8936

#Unit 2. Cellular Organization

When a kinetochore is unattached, the outer kinetochore component Knl1 is phosphorylated by the checkpoint kinase Mps1.
TLS Online TPP Program

#Id: 8937

#Unit 2. Cellular Organization

Phosphorylated Knl1 binds the checkpoint protein kinase Bub1-Bub3 and checkpoint protein BubR1. These three proteins, recruit the Mad1-Mad2 complex to the kinetochore.
TLS Online TPP Program

#Id: 8938

#Unit 2. Cellular Organization

The Mad1-Mad2 complex bound to a kinetochore adopts the active closed form (Mad2-C) and has the ability to convert inactive open Mad2 (Mad2-O) in the cytoplasm into active closed Mad2 is able to inhibit APC/Ccdc20