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TLS Online TPP Program

#Id: 6912

In heterozygotes DUPLICATIONS - The pairing and synapsis of homologous regions require that one or both chromosomes loop and twist. 



#Unit 8. Inheritance Biology #Structural and numerical alterations of chromosomes #Part B Pointers
PYQ Links
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Extensive Links
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TLS Online TPP Program

#Id: 9470

#Unit 4. Cell Communication and Cell Signaling

Phosphorylated STAT dissociates spontaneously from the receptor, and two phosphorylated STAT proteins form a homodimer.
TLS Online TPP Program

#Id: 9471

#Unit 4. Cell Communication and Cell Signaling

STAT5 becomes activated in erythroid progenitor cells and induces expression of the protein Bcl-xL.
TLS Online TPP Program

#Id: 9472

#Unit 4. Cell Communication and Cell Signaling

Two mechanisms for terminating cytokine signaling:
1. Short-term regulation: SHP1
2. Long-term regulation: SOCS proteins
TLS Online TPP Program

#Id: 9473

#Unit 4. Cell Communication and Cell Signaling

SHP1 a phosphotyrosine phosphatase, contains:
SH2 domain  & Phosphatase domain
TLS Online TPP Program

#Id: 9474

#Unit 4. Cell Communication and Cell Signaling

SHP1 
Binding of an SH2 domain to a phosphotyrosine in the activated receptor unmasks its phosphatase catalytic site
TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.