Multipotent adult stem cells play major roles in organisms with high regenerative capabilities, such as hydra, axolotl, and zebrafish.

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#Unit 5. Developmental Biology

In embryos whose mothers have mutant glp-1, ABp is transformed into an ABa cell

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#Unit 5. Developmental Biology

If the P2 cell is killed at the early 4-cell stage, the ABp cell does not generate its normal complement of cells

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#Unit 5. Developmental Biology

Cleavage type- Unequal radial holoblastic cleavage

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#Unit 5. Developmental Biology

Cortical Rotation The cortical cytoplasm has rotated 30º relative to the internal cytoplasm.

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#Unit 5. Developmental Biology

Gray Crescent 

The region opposite the point of sperm entry, where the greatest displacement of cytoplasm occurs (Gastrulation will begin)

Vegetal rotation: Vegetal cells asymmetrically press up against the inner blastocoel roof on the dorsal side.

Bottle cell formation and invagination: Localized apical constriction at the dorsal blastopore lip creates anisotropic forces that foster invagination.

Involution and cell migration: The leading edge of invaginating cells crawls up onto the blastocoel roof.

Convergence and extension: The targeted medial-to-lateral intercalation of cells on the midline (convergence) drives anterior-posterior axis elongation (extension).

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#Unit 5. Developmental Biology