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TLS Online TPP Program

#Id: 7024

The somatic cells of the hub create asymmetric proliferation by secreting the paracrine factor Unpaired onto the cells attached to them

#Unit 5. Developmental Biology #Basic concepts of development #Part B Pointers
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TLS Online TPP Program

#Id: 9707

#Unit 4. Cell Communication and Cell Signaling

Ligand binding and dissociation of the G protein subunits, the membrane-tethered Gβγ subunit binds the Ste5.
TLS Online TPP Program

#Id: 9708

#Unit 4. Cell Communication and Cell Signaling

Ste5 acts as a scaffold for assembling other components in the cascade Ste11, Ste7, and Fus3.
TLS Online TPP Program

#Id: 9709

#Unit 4. Cell Communication and Cell Signaling

Gβγ activates Cdc24, a GEF for Cdc42
TLS Online TPP Program

#Id: 9710

#Unit 4. Cell Communication and Cell Signaling

Cdc24 = SOS
Cdc42 = Ras
TLS Online TPP Program

#Id: 9711

#Unit 4. Cell Communication and Cell Signaling

GTP-bound Cdc42, binds to and activates the Ste20 kinase.
TLS Online TPP Program

#Id: 9712

#Unit 4. Cell Communication and Cell Signaling

Ste20 serves as a MAPKKK kinase.