TLS Online TPP Program

#Id: 1105

#Unit 2. Cellular Organization

Phosphorylation domain contains the canonical Asp351 phosphorylated.

TLS Online TPP Program

#Id: 1106

#Unit 2. Cellular Organization

Nucleotide binding domain serves as a built-in protein kinase that functions to phosphorylate the P domain.

TLS Online TPP Program

#Id: 1107

#Unit 2. Cellular Organization

Actuator domain has protein phosphatase activity and removes the phosphoryl group from the Asp residue

TLS Online TPP Program

#Id: 1108

#Unit 2. Cellular Organization

E1’s ion-binding sites are exposed to the cytoplasm, and it has high affinity for Na+ but low affinity for K+

TLS Online TPP Program

#Id: 1109

#Unit 2. Cellular Organization

E2’s ion binding sites are exposed to the exterior of the cell and it has low affinity for Na+ but high affinity for K+

TLS Online TPP Program

#Id: 1110

#Unit 2. Cellular Organization

Cardiac glycosides (e.g., ouabain and digitalis) are a class of drugs that inhibits Na+-K+ ATPase.