The mechanism for “bottom-up” specification of germ layers of the frog embryo resides in a set of mRNAs that are tethered to the vegetal cortex

TLS Online TPP Program

#Id: 7378

#Unit 5. Developmental Biology

Par-1 protein organizes microtubules specifically with their minus and plus ends at the anterior and posterior ends of the oocyte, respectively

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#Id: 7379

#Unit 5. Developmental Biology

Bicoid mRNA binds to dynein, a “minus-directed” motor protein associated with the nongrowing end of microtubules; dynein moves the bicoid mRNA to the anterior end of the egg. 

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#Id: 7380

#Unit 5. Developmental Biology

Oskar mRNA becomes complexed to kinesin I, a “plus-directed” motor protein that moves it toward the growing end of the microtubules at the posterior region, where Oskar protein can bind nanos mRNA

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#Id: 7381

#Unit 5. Developmental Biology

The inhibition of Oskar translation is mediated by two proteins- 

Bruno

Cup

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#Id: 7382

#Unit 5. Developmental Biology

TLS Online TPP Program

#Id: 7383

#Unit 5. Developmental Biology