Nurturing Life Sciences
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#Unit 5. Developmental Biology
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ACG harbours two transmembrane domains & localizes to the membrane of the prespore vesicles.
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ACG act as an osmosensor, so spores formed from the acg- cells will germinate irrespective of the osmotic conditions.
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Adenylate cyclase B (ACB) is normally expressed in prestalk cells, but is upregulated in the prespore region of acg null structures.
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In D. discoideum cAMP phosphodiesterase RegA plays a crucial role in regulating intracellular cAMP levels cells & level of PKA activity.
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RegA is activated by phosphorylation of an aspartate in its response regulator domain.