Plot of ln k versus 1/T gives a straight line with a slope (m) of –Ea/R and an intercept (b) of ln A. 

TLS Online TPP Program

#Id: 10417

#Unit 4. Cell Communication and Cell Signaling

Metastasis

Spread of cancer cells from their site of origin and establishment of areas of secondary growth

TLS Online TPP Program

#Id: 10418

#Unit 4. Cell Communication and Cell Signaling

Metastasis

cancer cells have acquired the ability to penetrate basement membranes using a cell protrusion called an invadopodium

TLS Online TPP Program

#Id: 10419

#Unit 4. Cell Communication and Cell Signaling

Epithelial-to-mesenchymal transition (EMT) 

play a crucial role in metastasis

TLS Online TPP Program

#Id: 10420

#Unit 4. Cell Communication and Cell Signaling

Heart of the EMT are two transcription factors, 

Snail and Twist

TLS Online TPP Program

#Id: 10421

#Unit 4. Cell Communication and Cell Signaling

Snail and Twist promote expression of genes involved in cell migration, loss of cell-cell adhesion, loss of cell polarity, and increase the production of proteases that digest the basement membrane

TLS Online TPP Program

#Id: 10422

#Unit 4. Cell Communication and Cell Signaling