The mouse zona pellucida is made of three major glycoproteins—ZP1, ZP2, and ZP3

TLS Online TPP Program

#Id: 7212

#Unit 5. Developmental Biology

Presentation of nonpeptide antigens derived from pathogens involves the nonclassical class I–like CD1 molecule

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#Id: 7213

#Unit 5. Developmental Biology

Class I presentation requires internal synthesis of virus protein, as shown by the requirement that the target cell be infected by live virus, and by the inhibition of class I presentation observed when protein synthesis was blocked by the inhibitor emetine

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#Id: 7214

#Unit 5. Developmental Biology

Class II presentation can occur with either live or replication-incompetent virus; protein synthesis inhibitors had no effect, indicating that new protein synthesis is not a necessary condition of class II presentation.

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#Id: 7215

#Unit 5. Developmental Biology

Class II, but not class I, presentation is inhibited by treatment of the cells with an agent that blocks endocytic processing within the cell (chloroquine).

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#Id: 7216

#Unit 5. Developmental Biology

T cell

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#Id: 7217

#Unit 5. Developmental Biology

T cells initiate the adaptive immune response by interacting MHC on antigen-presenting cells that have been exposed to pathogens.