Ran dependent mechanism for nuclear export of cargo proteins containing a leucine-rich nuclear-export signal (NES).

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#Id: 2110

#Unit 8. Inheritance Biology

Deletions are lethal in the homozygous state because all copies of any essential genes located in the deleted region are missing.

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#Id: 2111

#Unit 8. Inheritance Biology

Heterozygous condition may produce imbalances in the amounts of gene products similar to those produced by extra gene copies.

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#Id: 2112

#Unit 8. Inheritance Biology

Pseudodominance- Recessive allele owing to a deletion on the homologous chromosome.

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#Id: 2113

#Unit 8. Inheritance Biology

Haploinsufficiency- One copy of the gene is missing, a mutant phenotype is produced.

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#Id: 2114

#Unit 8. Inheritance Biology

Deletions can be detected cytologically by studying the banding patterns in stained chromosomes.

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#Id: 2115

#Unit 8. Inheritance Biology

Large aberrations can be detected by examination of mitotic chromosomes that have been stained with banding agents such as quinacrine or Giemsa.