Optical rotation

TLS Online TPP Program

#Id: 10501

#Unit 4. Cell Communication and Cell Signaling

Engulfment involves the assembly of a halo of actin in the engulfing cell around the dying cell, triggered by activation of Rac.

TLS Online TPP Program

#Id: 10502

#Unit 4. Cell Communication and Cell Signaling

Four genes play an essential role in controlling apoptosis during C. elegans development: 

ced-3, ced-4, ced-9, and egl-1

TLS Online TPP Program

#Id: 10503

#Unit 4. Cell Communication and Cell Signaling

In C. elegans BH3-only protein EGL-1 initiate apoptosis by binding to and inactivating CED-9

TLS Online TPP Program

#Id: 10504

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 protein = C. elegans CED-9 protein

(23% identical in aa sequence)

TLS Online TPP Program

#Id: 10505

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins act as regulators that suppress the apoptotic pathway

TLS Online TPP Program

#Id: 10506

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins contain a single TM domain and are localized to the outer mitochondrial membrane