Matrix-targeting sequences

Located at the N-terminus

Usually 20–50 amino acids in length

Rich in hydrophobic amino acids, positively charged basic amino acids (arginine & lysine), and hydroxylated ones (serine and threonine)

Amphipathicity of matrix-targeting sequences is critical to their function

TLS Online TPP Program

#Id: 10113

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 6062

#Unit 10. Ecological Principles

Zone of Lake 

TLS Online TPP Program

#Id: 7863

#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 1151

#Unit 7. System Physiology – Animal

Glomerular filtration barrier is selective in determining which molecules will filter, based on their,

1. Size 

2. Electrical charge

TLS Online TPP Program

#Id: 9622

#Unit 4. Cell Communication and Cell Signaling

Monomeric state of the EGF receptor,

activation loop is situated in the active site of the kinase near the interface of the N and C lobes, blocking the site’s activity; in this way the kinase is maintained in the inactive or “off” state