KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 10442

#Unit 4. Cell Communication and Cell Signaling

Potent form of benzo(a)pyrene induces inactivating mutations at codons 175, 248, & 273 of the p53 gene

TLS Online TPP Program

#Id: 10443

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10444

#Unit 4. Cell Communication and Cell Signaling

Somatic mutations can be grouped into three types: Single nucleotide variants (SNVs, or point mutations) Insertions or deletions (Indels)

Structural variants (SVs)

TLS Online TPP Program

#Id: 10445

#Unit 4. Cell Communication and Cell Signaling

A typical tumor contain 5000 SNVs, 500 Indels, and 

50 SVs

TLS Online TPP Program

#Id: 10446

#Unit 4. Cell Communication and Cell Signaling

Rous sarcoma virus is a retrovirus whose RNA genome is reverse transcribed into DNA, which is incorporated into the host-cell genome

TLS Online TPP Program

#Id: 10447

#Unit 4. Cell Communication and Cell Signaling

Oncogenic transforming viruses RSV contain an

oncogene — v-src gene