KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 7506

#Unit 4. Cell Communication and Cell Signaling

RAG1 subunit and contains two aspartic acid residues and one glutamic acid residue (D600, D708, and E962, respectively). This active site “DDE motif” is found in many enzymes that cleave DNA

TLS Online TPP Program

#Id: 7507

#Unit 4. Cell Communication and Cell Signaling

ZnA and ZnB on RAG1 are regions of the proteins that form zinc fingers, elongated protein domains stabilized by the coordination of a Zn ion.

TLS Online TPP Program

#Id: 7508

#Unit 4. Cell Communication and Cell Signaling

The ZnA region of the protein assists in the initial RAG1 binding to active chromatin via its ability to interact with histone H3.

TLS Online TPP Program

#Id: 9872

#Unit 4. Cell Communication and Cell Signaling

Innate immunity is the most ancient form of defense, found in all multicellular plants and animals.

TLS Online TPP Program

#Id: 9873

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9874

#Unit 4. Cell Communication and Cell Signaling

The innate immune system includes physical and chemical—as well as cellular responses