Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 10405

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10406

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10407

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10408

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10409

#Unit 4. Cell Communication and Cell Signaling

Chromothripsis

entire chromosomes or large parts of chromosomes are shattered and stitched together, leading to dozens or sometimes even hundreds of rearrangements

TLS Online TPP Program

#Id: 10410

#Unit 4. Cell Communication and Cell Signaling

Warburg effect

Cancer cells and proliferating cells convert most glucose to lactate regardless of whether oxygen is present or not.