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TLS Online TPP Program

#Id: 8276

#Unit 1. Molecules and their Interaction Relevant to Biology #Stablizing interactions (Van der Waals, electrostatic, hydrogen bonding, hydrophobic interaction) #Part B Pointers
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TLS Online TPP Program

#Id: 9956

#Unit 4. Cell Communication and Cell Signaling

Human genome encodes 19 different Wnt proteins, and essential for critical developmental events, including:
Brain development
Limb patterning
Organogenesis
Formation of osteoblasts
TLS Online TPP Program

#Id: 9957

#Unit 4. Cell Communication and Cell Signaling

Wnts are paracrine factors that make up a large family of cysteine-rich glycoproteins
TLS Online TPP Program

#Id: 9958

#Unit 4. Cell Communication and Cell Signaling

Structure of Wnt proteins 
22 cysteine residues, which form disulfide bridges that maintain a globular secondary structure.
TLS Online TPP Program

#Id: 9959

#Unit 4. Cell Communication and Cell Signaling

Wnt = wingless + integrated
TLS Online TPP Program

#Id: 9960

#Unit 4. Cell Communication and Cell Signaling

Wnt proteins are modified by linkage of a monounsaturated fatty acid, palmitoleic acid, to a serine in the middle of the protein.
TLS Online TPP Program

#Id: 9961

#Unit 4. Cell Communication and Cell Signaling

Lipid modifications of Wnt are catalyzed by the 
O-acetyltransferase Porcupine.