The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)

TLS Online TPP Program

#Id: 8376

#Unit 2. Cellular Organization

Myosin 

Actin-based motors powered by ATP hydrolysis.

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#Id: 8377

#Unit 2. Cellular Organization

Myosins have 

Motor head domain

Lever-arm neck domain

Cargo-binding tail domain

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#Id: 8378

#Unit 2. Cellular Organization

The first myosin discovered

Myosin II, was isolated from skeletal muscle.

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#Unit 2. Cellular Organization

Three classes of myosins:

Myosin I

Myosin II

Myosin V

TLS Online TPP Program

#Id: 8380

#Unit 2. Cellular Organization

single head domain

Function- Membrane association, endocytosis

TLS Online TPP Program

#Id: 8381

#Unit 2. Cellular Organization

Myosin II

Two heads and assembles into bipolar filaments

Small and non-processive

Function- Contraction