Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin. 

TLS Online TPP Program

#Id: 10297

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10298

#Unit 4. Cell Communication and Cell Signaling

T-cell education

TLS Online TPP Program

#Id: 10299

#Unit 4. Cell Communication and Cell Signaling

Lineage commitment

TLS Online TPP Program

#Id: 10300

#Unit 4. Cell Communication and Cell Signaling

T-Cell Activation and Differentiation

TLS Online TPP Program

#Id: 10301

#Unit 4. Cell Communication and Cell Signaling

Three signals are required for activation of a naïve T cell

TLS Online TPP Program

#Id: 10302

#Unit 4. Cell Communication and Cell Signaling

Positive Costimulatory Receptors: ICOS

ICOS binds to another member of the growing B7 family, ICOS-ligand (ICOS-L), which is also expressed on a subset of activated APCs.

ICOS plays a key role in maintaining the activity of already differentiated effector and memory T cells.