In the cytoplasm, KASH proteins can bind directly to microfilaments and indirectly to microtubules and Ifs through association with motor proteins and plakins, respectively.

TLS Online TPP Program

#Id: 6316

#Unit 3. Fundamental Processes

Readthrough transcripts refer to the fraction of transcripts that are not stopped by the terminator.  Furthermore, the termination event can be prevented by specific ancillary factors that interact with RNA and/or RNA polymerase, a situation referred to as antitermination.

TLS Online TPP Program

#Id: 8920

#Unit 2. Cellular Organization

During anaphase, when cyclin B-CDK1 activity is extinguished but Aurora and Polo kinases are still active, Aurora B phosphorylates MKLP1 and displaces the 14-3-3, allowing compact the spindle midzone.

TLS Online TPP Program

#Id: 10459

#Unit 4. Cell Communication and Cell Signaling

Inappropriate production of nuclear transcription factors such as FOS, JUN, and MYC can induce transformation.

TLS Online TPP Program

#Id: 9937

#Unit 4. Cell Communication and Cell Signaling

Intracellular bacterial

Intracellular bacterial infections tend to induce a cell-mediated immune response, specifically DTH. 

In this response, cytokines secreted by CD4+ T cells are important—most notably IFN-ϒ, which activates macrophages.

TLS Online TPP Program

#Id: 10397

#Unit 4. Cell Communication and Cell Signaling

Mutations in three broad classes of genes have been implicated in the onset of cancer. 

Protooncogenes

Tumor-suppressor genes

genome maintenance genes