Centralspindlin-Ect2 complex catalyzes activation of RhoA, leading to cleavage furrow formation and division of the cytoplasm to form two completely separate cells.

TLS Online TPP Program

#Id: 1511

#Unit 2. Cellular Organization

Tubulin dimers in which the β-subunit has bound GTP are added preferentially to (+) end of the microtubule.

TLS Online TPP Program

#Id: 1512

#Unit 2. Cellular Organization

In a microtubule,

The end with exposed β-subunits is the (+) end

The end with exposed α-subunits is the (−) end

 

TLS Online TPP Program

#Id: 1513

#Unit 2. Cellular Organization

Microtubules exist in three forms:

Singlet

Doublet

Triplet

TLS Online TPP Program

#Id: 1514

#Unit 2. Cellular Organization

Most microtubules in a cell consist of a simple tube, a singlet microtubule, built from 13 protofilaments. 

TLS Online TPP Program

#Id: 1515

#Unit 2. Cellular Organization

Doublet contains one complete 13-protofilament microtubule (A tubule) and one additional tubules (B tubule) consisting of 10 protofilaments.

 

TLS Online TPP Program

#Id: 1516

#Unit 2. Cellular Organization

Triplet contains one complete 13-protofilament microtubule (A tubule) and two additional tubules (B & C tubule) consisting of 10 protofilaments each.