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Surveillance mechanisms known as checkpoint pathways responsible for the extraordinarily high fidelity of cell division, ensuring that each daughter cell receives the correct number of accurately replicated chromosomes

#Unit 2. Cellular Organization #CELL CYCLE #Part B Pointers
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#Unit 5. Developmental Biology

Cells capable of stem cell mediated regeneration are the same pluripotent stem cells that repair and replace body parts.

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#Unit 5. Developmental Biology

Regeneration blastema forms from pluripotent stem cells called clonogenic neoblasts (cNeoblasts).

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#Unit 5. Developmental Biology

Clonogenic neoblasts

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#Unit 5. Developmental Biology

Clonogenic neoblasts can migrate to a wound site and regenerate the tissue.



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#Unit 5. Developmental Biology

Each pluripotent neoblast generates a colony of neoblast cells in the flatworm.

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#Unit 5. Developmental Biology

First possible mechanisms for neoblast specification during regeneration:
A single pluripotent neoblast is responsible for generating new cell progenitors that form the multipotent cells of the blastema.



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