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TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling #G Protein–Coupled Receptors #Part B Pointers
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TLS Online TPP Program

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#Unit 2. Cellular Organization

Thick-filament regulation
Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 8388

#Unit 2. Cellular Organization

Smooth muscle cells and nonmuscle cells are regulated by:
Norepinephrine, angiotensin, endothelin, histamine

TLS Online TPP Program

#Id: 8389

#Unit 2. Cellular Organization

Smooth muscle contraction is regulated by the cycling of myosin II between on and off states.

TLS Online TPP Program

#Id: 8390

#Unit 2. Cellular Organization

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.


TLS Online TPP Program

#Id: 8391

#Unit 2. Cellular Organization

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 8392

#Unit 2. Cellular Organization

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC. 

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