Infection resistance - The ability of a host to prevent an infection from occurring. 

Infection tolerance - The ability of a host to minimize the harm once an infection has occurred. 

Parasite load - The number of parasites of a given species that an individual host can harbor.

Vertical transmission - When a parasite is transmitted from a parent to its offspring.

TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.

TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 

expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods

TLS Online TPP Program

#Id: 9477

#Unit 4. Cell Communication and Cell Signaling

All SOCS proteins contains:

SH2 domain

SOCS box

TLS Online TPP Program

#Id: 9478

#Unit 4. Cell Communication and Cell Signaling

SOCS box, 

Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome

TLS Online TPP Program

#Id: 9479

#Unit 4. Cell Communication and Cell Signaling

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

TLS Online TPP Program

#Id: 9480

#Unit 4. Cell Communication and Cell Signaling