Activated PKB also promotes survival of many cultured cells by phosphorylating the Forkhead transcription factor FOXO3a on multiple serine and threonine residues.

TLS Online TPP Program

#Id: 6998

#Unit 5. Developmental Biology

Numerous adult organs possess adult stem cells, which in most cases are multipotent.

TLS Online TPP Program

#Id: 6999

#Unit 5. Developmental Biology

Unlike pluripotent stem cells, adult or multipotent stem cells in culture not only have a restricted array of cell types that they can create, but they also have a finite number of generations for self-renewal.

TLS Online TPP Program

#Id: 7000

#Unit 5. Developmental Biology

Limited renewal of adult stem cells may contribute to aging..

TLS Online TPP Program

#Id: 7001

#Unit 5. Developmental Biology

When a multipotent stem cell divides asymmetrically, its maturing daughter cell often goes through a transition stage as a progenitor or transit-amplifying cell, as is seen in the formation of blood cells, sperm, and neurons.

TLS Online TPP Program

#Id: 7002

#Unit 5. Developmental Biology

Progenitor cells are not capable of unlimited self-renewal; rather, they have the capacity to divide only a few times before differentiating.

TLS Online TPP Program

#Id: 7003

#Unit 5. Developmental Biology

Although limited but Progenitor cells proliferation serves to amplify the pool of progenitors before they terminally differentiate.