The cytosolic phosphoserine binding protein 14-3-3 then binds to phosphorylated FOXO3a and sequesters it in the cytosol.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase