Inflammation

Tissue response to infection or damage which serves to eliminate

Classic signs of acute inflammation are heat (calore), pain (dolore), redness (rubor), swelling (tumor), and loss of function (functio laesa).

TLS Online TPP Program

#Id: 349

#Unit 1. Molecules and their Interaction Relevant to Biology

The oxaloacetate is converted to PEP by phosphoenolpyruvate carboxykinase. This Mg2+ dependent reaction requires GTP as the phosphoryl group donor.

TLS Online TPP Program

#Id: 353

#Unit 1. Molecules and their Interaction Relevant to Biology

Transketolase requires the cofactor thiamine pyrophosphate (TPP)

TLS Online TPP Program

#Id: 354

#Unit 1. Molecules and their Interaction Relevant to Biology

Acetyl-CoA and NADH are potent allosteric inhibitors of the enzyme. 

TLS Online TPP Program

#Id: 355

#Unit 1. Molecules and their Interaction Relevant to Biology

Acetyl-CoA inhibits the transacetylase component whereas NADH inhibits the dihydrolipoyl dehydrogenase component. 

TLS Online TPP Program

#Id: 356

#Unit 1. Molecules and their Interaction Relevant to Biology

The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)

TLS Online TPP Program

#Id: 359

#Unit 1. Molecules and their Interaction Relevant to Biology

Eukaryotic cells have two isozymes of aconitase

• The mitochondrial isozyme (convert citrate to isocitrate in the citric acid cycle)

• The cytosolic isozyme