Nurturing Life Sciences
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Adenoviruses and cytomegalo virus use to reduce the surface expression of class I MHC molecules,
Measles virus and HIV, reduce levels of class II MHC molecules on the surface,
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#Unit 4. Cell Communication and Cell Signaling
This results in continuous activation of the AC of intestinal epithelial cells, chronically active PKA which phosphorylates the CFTR Cl- channel and a Na-H exchanger in the intestinal epithelial cells.
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The resultant efflux of NaCl triggers massive water loss through the intestine as cells respond to the ensuing osmotic imbalance causes severe dehydration and electrolyte loss.
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