Cell wall endotoxins of some gram-negative bacteria activate macrophages, resulting in release of high levels of IL-1 and TNF-α, which can cause septic shock.

TLS Online TPP Program

#Id: 6550

#Unit 7. System Physiology – Animal

Removal of insulin, the plasma membrane GLUT4 is internalized by endocytosis and eventually transported to GSVs

TLS Online TPP Program

#Id: 4761

#Unit 5. Developmental Biology

PAL-1 is regulated by the MEX-3 protein, an RNA binding protein that inhibit the translation of pal-1 mRNA.

TLS Online TPP Program

#Id: 8750

#Unit 1. Molecules and their Interaction Relevant to Biology

The lack of an ordered structure can facilitate a kind of functional promiscuity, allowing one protein to interact with multiple partners. Some intrinsically disordered proteins act to inhibit the action of other proteins by an unusual mechanism: wrapping around their protein targets.

TLS Online TPP Program

#Id: 6770

#Unit 3. Fundamental Processes

Upf1 is the first NMD protein to act, binding to the terminating ribosome—specifically to its release factor complex.

TLS Online TPP Program

#Id: 10471

#Unit 4. Cell Communication and Cell Signaling

A mutation, valine to glutamine in the TM region of the HER2 receptor causes dimerization of the receptor, even in the absence of the ligand, transforming it into the oncoprotein NEU, a constitutively active protein tyrosine kinase.