Malaria (Parasitic)

Sporozoites enter the bloodstream by mosquito.

The sporozoites migrate to the liver, where they multiply, transforming liver hepatocytes into giant multinucleate schizonts, which release thousands of merozoites into the bloodstream. 

TLS Online TPP Program

#Id: 6382

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 6383

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 6384

#Unit 2. Cellular Organization

The DNA-binding domain occupies residues 1–59. It contains two a-helices separated by a turn. This is a common DNA-binding motif known as the HTH (helix-turn-helix); the two a-helices fit into the major groove of DNA

TLS Online TPP Program

#Id: 6385

#Unit 2. Cellular Organization

Promoter mutations are also cis-acting. If they prevent RNA polymerase from binding at P-lac, the structural genes are never transcribed.

TLS Online TPP Program

#Id: 6386

#Unit 2. Cellular Organization

Mutants that cannot be expressed at all are called uninducible. Mutants that are continuously expressed are called constitutive mutants.

TLS Online TPP Program

#Id: 6387

#Unit 2. Cellular Organization

Cryptic mutants” of lac operon make b-galactosidase but still could not grow on lactose means they are essentially Y-