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TLS Online TPP Program

#Question id: 1034

A new drug is developed that targets and binds to the lipid A portion of LPS from Gram negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,

#Unit 4. Cell Communication and Cell Signaling

  1. we should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.

  2. we should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.

  3. we should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.

  4. we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. It wouldn't help humans who have septic shock at all.

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TLS Online TPP Program

#Question id: 7281

#Unit 5. Developmental Biology

Evolutionary conservation of homeotic gene organization and transcriptional expression in fruit flies and mice is seen in the similarity between the Hom-C cluster on Drosophila chromosome 3 and the four Hox gene clusters in the mouse genome.

 

According to this figure, Which of the following statement is correct?
TLS Online TPP Program

#Question id: 7282

#Unit 5. Developmental Biology

In humans, neural tube closure defects occur in about 1 in every 1000 live births. Failure to close the neural tube can result from both genetic and environmental causes. A recent report has demonstrated that zinc deficiency disrupts neural tube closure by:
TLS Online TPP Program

#Question id: 7283

#Unit 5. Developmental Biology

The Drosophila orthodenticle gene and the vertebrate Otx genes are homologous and provide a good example of the conservation of gene function during evolution. Which of the following statement is correct regarding to the expression of gene expression.
TLS Online TPP Program

#Question id: 7284

#Unit 5. Developmental Biology

Choose the correct match.

GenesAxis polarity
a. Maternal deficiency of gurkeni. Posteriorization of follicle cells
b. Maternal deficiency of torpedoii. Ventralization of embryo
c. Maternal deficiency of tolliii. Dorsalization of embryo
iv. No anterior posterior axis
TLS Online TPP Program

#Question id: 7285

#Unit 5. Developmental Biology

During xenopus gastrulation, C3a functions as a short-range chemoattractant to guide the radial intercalation movements of cells. If Knockdown of C3a with antisense morpholinos results:
TLS Online TPP Program

#Question id: 7286

#Unit 5. Developmental Biology

Which of the floral whorls is affected in apetala 3/pistillata (ap3/pi) mutants?